IFN-stimulated gene – Communicable Diseases Research

Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection

Article

Published on 2022-09-302022-11-16
Journal: Viruses
[Category] SARS, 치료법,

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

USP22는 STING의 활성화를 통해 III형 인터페론 신호 전달 및 SARS-CoV-2 감염을 제어합니다

Article

Published on 2022-08-062022-09-11
Journal: Cell Death & Disease
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] absence Activation Antiviral basal causative agent Control COVID-19 pandemic de novo Defense enzyme epithelial cells exogenous IFN expression function Host identify IFN IFN signaling IFN-stimulated gene IFN-stimulated genes IFN-λ IFNs implication interferons interferons (IFNs interferons (IFNs) intestinal epithelial cell involved ISG ISGs long-lasting Particles pattern Pattern recognition Pattern recognition receptors PRRs receptor reversed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion Signaling STAT Stat1 STING tumorigenesis Type Type III IFN Type III IFNs type III interferon USP22 viral infection viral replication
[DOI] 10.1038/s41419-022-05124-w PMC 바로가기 [Article Type] Article

Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity

COVID-19 환자의 항-IFN-α/-ω 중화 항체는 IFN 반응의 하향조절 및 질병 중증도의 실험실 바이오마커와 상관관계가 있습니다

Article

Published on 2022-07-012022-09-11
Journal: European Journal of Immunology
[Category] MERS, 바이오마커, 진단, 치료기술,

[키워드] Antiviral association autoantibodies autoantibodies, SARS-CoV-2 binding binding antibodies binding antibody biochemical characterized COVID-19 COVID-19 patient cross-reactivity CRP D-dimer dimer disease severity downregulation fluctuation Gene Expression hematological parameters ICU IFN IFN response IFN-stimulated gene IFN-stimulated genes IFN-α interferon ISG ISGs laboratory biomarker laboratory biomarkers LDH male Neutralizing antibodies neutralizing antibodies. neutralizing antibody outcome Patient patients positive positive patient proportion quantified reduced respiratory Respiratory samples screened sera serum severe COVID-19 shown specificity subset tested transcript levels
[DOI] 10.1002/eji.202249824 PMC 바로가기 [Article Type] Article

Gene Set Enrichment Analysis Reveals That Fucoidan Induces Type I IFN Pathways in BMDC

유전자 세트 농축 분석을 통해 후코이단이 BMDC에서 I형 IFN 경로를 유도한다는 사실이 밝혀졌습니다

Article

Published on 2022-05-272022-09-11
Journal: Nutrients
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] activate Analysis Antigen presentation Antiviral antiviral activity BMDC CD40 CD80 cytometric DEGs dendritic dendritic cell dendritic cells differentially expressed gene Differentially expressed genes differentially expressed genes (DEGs) driven by enrichment enrichment analysis Flow Flow cytometric analysis fucoidan gene set enrichment analysis gene set enrichment analysis (GSEA) greater GSEA highlighting IFN IFN-stimulated gene immune cells Inflammatory response innate immune Innate immune cells IRF ISG ISGs maturation mechanism MHCII NF-κB NLR nucleic acid pathway Pathways polysaccharide potential mechanism Prevent PRR receptor SARS-CoV-2 Signaling STAT STING sulfated surface marker TLR transcription factors transcriptional change transcriptionally Transcriptome transcriptome change treat Type type I Type I IFN type I IFN. type I interferon upregulated viral infections viruses
[DOI] 10.3390/nu14112242 PMC 바로가기 [Article Type] Article

The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λ

Research Article

Published on 2021-12-222022-10-30
Journal: mSphere
[Category] Coronavirus,

[키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting
[DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

초기 IFN-α 시그니처와 지속적인 기능 장애는 심각한 COVID-19에서 NK 세포의 구별되는 특징입니다

Multicenter Study

Published on 2021-11-092022-09-11
Journal: Immunity
[Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis anti-SARS-CoV-2 Antiviral Cell Clinical course Cohort coronavirus coronavirus disease COVD-19 COVID-19 disease Diseases dysfunction elevated exhibited expression feature fibrosis functional IFN IFN-stimulated gene IFN-stimulated genes IFN-α Immunopathogenesis independent indicate induced genes innate immune system interferon involved ISGs longitudinal Longitudinal analyses lung Lung disease Lung fibrosis moderate Moderate COVID-19 natural killer Necrosis NK cell NK cells outcome Patient performed plasma Plasma levels proteomics respiratory scRNA-seq severe severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling single-cell Single-cell transcriptomics symptom onset TNF TNF response TNF responses transcriptomics Tumor tumor necrosis tumor necrosis factor type 1 IFN. upregulation
[DOI] 10.1016/j.immuni.2021.09.002 PMC 바로가기 [Article Type] Multicenter Study

Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child

IRF9 결핍 아동에서 SARS-CoV-2의 단일 클론 항체 매개 중화

Case Reports

Published on 2021-10-262022-09-10
Journal: Proceedings of the National Academy of Sciences of
[Category] MERS, SARS, 변종, 진단,

[키워드] antibody Antiviral autoantibodies autoantibody Blood blood type Casirivimab caused children clinical manifestation clinical manifestations component Course COVID-19 COVID-19 pneumonia Critical deficiency expression girl high risk IFN IFN-stimulated gene IFN-stimulated genes IFN-α2 IFNs Imdevimab Immunity Infection Influenza influenza pneumonia inherited deficiency inherited primary immunodeficiency interferon interferons IRF9 lack leukocyte leukocytes life-threatening monoclonal antibodies monoclonal antibody nasal neutralization Neutralizing neutralizing monoclonal antibody overcome Patient peaked Pneumonia prevented reported respiratory respiratory tract infection response risk RNA-Seq SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 virus secretion selected Significance transcription factor type I type I and III interferons type I IFNs type I interferon Type III IFN upper respiratory tract upper respiratory tract infection Viremia virus
[DOI] 10.1073/pnas.2114390118 PMC 바로가기 [Article Type] Case Reports

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article

Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome

급성 호흡 곤란 증후군이 있는 중환자 COVID-19 환자의 IFN-I 활성 및 면역 프로파일에 대한 종단 평가

Clinical Trial

Published on 2021-04-122022-08-13
Journal: Critical Care
[Category] MERS, 바이오마커, 임상,

[키워드] acute respiratory distress acute respiratory distress syndrome alteration appear ARDS ARDS patient ARDS patients Bacterial sepsis cellular COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine cytokine levels Cytokines decrease described Elevation expression followed by Hospital stay ICU admission IFN response IFN-I IFN-stimulated gene IFN-stimulated genes IFNα2 immune immune parameter Immune profile immune response immune responses immuno-inflammatory Immunosuppression intensity ISG longitudinal longitudinal immune monitoring lymphocyte Lymphocyte count marker mHLA-DR non-survivor normal values Occurrence outcome pandemic plasma question respiratory distress Result SARS-CoV2 infection Secondary infection secondary infections Sepsis similarities similarity supplementary material Survivors syndrome TNF-α Type-I IFN
[DOI] 10.1186/s13054-021-03558-w PMC 바로가기 [Article Type] Clinical Trial

Eltrombopag inhibits Type I interferon-mediated antiviral signaling by decreasing cellular iron

Article

Published on 2021-04-012023-06-13
Journal: Biochemical pharmacology
[Category] B형 간염,

[키워드] Eltrombopag IFN-stimulated gene Interferon-α iron chelation reactive oxygen species thrombocytopenia Viral hepatitis.
[DOI] 10.1016/j.bcp.2021.114436 PMC 바로가기